|Year : 2015 | Volume
| Issue : 1 | Page : 40-41
Esophageal squamous papilloma
Seham M Seif1, Ahmed Y Altonbary1, Wagdi F Elkashef2
1 Department of Hepatology and Gastroenterology, Mansoura Specialized Medical Hospital, Mansoura, Egypt
2 Department of Pathology, Mansoura Faculty of Medicine, Mansoura, Egypt
|Date of Submission||01-Nov-2014|
|Date of Acceptance||10-Nov-2014|
|Date of Web Publication||27-Apr-2015|
Seham M Seif
Mansoura Faculty of Medicine, Mansoura 35516
Source of Support: None, Conflict of Interest: None
Squamous papilloma of the esophagus is a rare benign tumor with less than 200 cases reported in the literature. The etiology and pathogenesis appear to be related to an inflammatory-reparatory type, such as chronic gastroesophageal reflux, esophagitis, trauma, chemical irritants, and viruses. We present the case of a young female patient with esophageal squamous papilloma discovered accidently during screening upper gastrointestinal endoscopy.
Keywords: Esophagus, human papillomavirus, squamous papilloma
|How to cite this article:|
Seif SM, Altonbary AY, Elkashef WF. Esophageal squamous papilloma. Egypt J Intern Med 2015;27:40-1
| Introduction|| |
Squamous papilloma of the esophagus is a rare benign tumor with less than 200 cases reported in the literature . The prevalence of endoscopically diagnosed papilloma of the esophagus has been reported in only a few series and varies from 0.01 to 0.43% , and only seven squamous papillomas of the esophagus were recognized in 52 148 autopsies (0.013%) reported up to 1968 . In addition, a case of squamous cell papillomatosis of the esophagus has been described in a patient following placement of a self-expanding metal stent .
| Case report|| |
A 46-year-old women presented to our unit for screening upper gastrointestinal endoscopy before interferon therapy. The patient had chronic hepatitis C with mild splenomegaly. The endoscopy revealed a diminutive polypoid lesion in the upper third of the esophagus [Figure 1], which was removed with biopsy forceps [Figure 2]. Histological examination of the specimens was compatible with esophageal squamous papilloma with no evidence of viral inclusions [Figure 3] and [Figure 4].
|Figure 1: Endoscopic image showing a diminutive polypoid lesion in the upper third of esophagus.|
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|Figure 2: Endoscopic image showing removal of the lesion with biopsy forceps.|
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|Figure 3: Hyperplastic stratified squamous epithelium with hyperkeratosis.|
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|Figure 4: Polypoid lesion covered by hyperplastic stratified squamous epithelium. The connective tissue core showing mild inflammatory reaction.|
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| Discussion|| |
Esophageal squamous papilloma is an uncommon benign squamous epithelial polypoid tumor and is usually identified as a solitary lesion of the lower esophagus . The etiology and pathogenesis of esophageal squamous papilloma appear to be related to an inflammatory-reparatory type, such as chronic gastroesophageal reflux, esophagitis, trauma, chemical irritants, and viruses . Their malignant potential is still unclear, and it has been proposed that human papillomavirus plays an etiopathogenic role; however, human papillomavirus is not consistently identified . It occurs in patients across a wide age range, mostly in adults aged between 18 and 80 years, with an average of 50 years at the time of diagnosis . Generally, a papilloma appears as a single, round, mulberry-like or dome-shaped elevated solid formation that is well-distinguished from the surrounding tissue. Some authors have reported multiple lesions, but only a few cases of esophageal papillomatosis have been reported ,. Follow-up is still rather insufficient in the literature. Thirty-five patients were followed up from 2 weeks to a maximum of 4 years. In two of them, the papilloma gradually disappeared and reached complete regression without special treatment. Two other papillomas had grown in diameter during the period of 6 months and 3 years. Three lesions recurred after 2, 6 months, and 1 year from endoscopic removal .
| Acknowledgements|| |
Conflicts of interest
There are no conflicts of interest.
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[Figure 1], [Figure 2], [Figure 3], [Figure 4]