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REVIEW ARTICLE
Year : 2015  |  Volume : 27  |  Issue : 2  |  Page : 45-47

Looking for the early marker of renal injury


Department of Internal Medicine and Nephrology, Cairo University, Giza, Egypt

Correspondence Address:
Ahmed S.A. Zaky
Department of Internal Medicine and Nephrology, Cairo University, Giza
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-7782.159446

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Acute Kidney Injury is a complex and increasingly common syndrome. Practically all available markers reflect functional impairment rather than a true direct mark of cellular injury. An ideal AKI biomarker should be accurate, reliable, easy to measure with a standard assay, noninvasive, reproducible, and sensitive and specific with defined cutoff values. Studies have identified a relatively small number of genes that are specifically altered in acute renal tubular injury. Kim-1 is one of the best-characterized urinary biomarkers to date in both experimental animals and humans with renal disease. Also NGAL is at the top of many researchers' lists. Other biomarkers include IL-18, N-acetyl-β-d-glucosaminidase, and urinary liver-type fatty acid binding protein.


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