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ORIGINAL ARTICLE
Year : 2017  |  Volume : 29  |  Issue : 3  |  Page : 117-121

Serum chemerin and diabetic retinopathy in type 2 diabetic patients


1 Assistant Professor in Internal Medicine Department, Faculty of Medicine, Menoufia University, Alexandria, Egypt
2 Lecturer in Ophthalmology Department, Faculty of Medicine, Menoufia University, Alexandria, Egypt
3 Assistant Prof Clinical Pathology, Pharmacology and Toxicology Department, Faculty of Pharmacy and Drug Manufacturing, Pharos University, Alexandria, Egypt

Correspondence Address:
Alaaeldin Abdelsalam Dawood
5 Fatma Elyosef Street, Sporting, Alexandria
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejim.ejim_30_17

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Background Diabetic retinopathy (DR) is one of the microvascular complications of type 2 diabetes mellitus (T2DM). There is a need to find a reliable screening biomarker to help in the early diagnosis of this complication. The aim of the work was to study the relation between serum chemerin and DR in T2DM patients. Patients and methods This study was conducted on 80 T2DM patients in addition to 20 healthy individuals who served as a control group. The participants were grouped into four groups: the T2DM group, the nonproliferative diabetic retinopathy (NPDR) group, the proliferative diabetic retinopathy (PDR) group, and the control group. Laboratory investigations were performed to all participants, which included glycosylated hemoglobin (HbA1c), serum creatinine, lipid profile, urine albumin/creatinine ratio, C-reactive protein (CRP), and serum chemerin. Fundus examination was carried out to all participants by an expert ophthalmologist. Results Serum chemerin was significantly higher in the PDR group compared with the other groups, in the NPDR group compared with the T2DM group and controls, and in the T2DM group compared with controls. There was a positive significant correlation between serum chemerin and BMI, HbA1c, diabetes mellitus duration, serum total cholesterol, triglycerides, low density lipoprotein, and CRP and a negative significant correlation between serum chemerin and high density lipoprotein in diabetic patients. Conclusion From this study, we can conclude that serum chemerin is significantly higher in patients with DR compared with diabetic patients without retinopathy and in PDR patients compared with NPDR patients. There is a positive correlation between serum chemerin and CRP, BMI, and lipid profile.


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