• Users Online: 298
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2017  |  Volume : 29  |  Issue : 4  |  Page : 164-169

Microscopic colitis in Egyptian population: study of some contributing factors and role of chromogranin A as a diagnostic marker


1 Department of Internal Medicine and Gastroenterology, Faculty of Medicine, October 6 University, Egypt
2 Department of Internal Medicine and Gastroenterology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Correspondence Address:
Mohamed S Gomaa
Department of Internal Medicine and Gastroenterology, Faculty of Medicine, October 6 University, Cairo
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejim.ejim_36_17

Rights and Permissions

Background Microscopic colitis (MC) and irritable bowel syndrome (IBS) have similar symptoms and a normal endoscopic appearance, as well as normal radiologic findings. Several studies have shown that MC can be mistakenly diagnosed as IBS. Over recent decades, MC has emerged as a common cause of diarrhea, especially in middle-aged or older women, and the disease is regarded as a subgroup within inflammatory bowel disease. The prevalence of MC in Egyptian patients with chronic watery nonbloody diarrhea is high when compared with that in developed countries. MC mainly affects young and middle-aged patients, and it is more commonly of the lymphocytic type. Chromogranin A is a common marker for endocrine cells, and the present finding suggests that colonic hormones are involved in the pathophysiology of lymphocytic colitis (LC). The chromogranin cell density seems to be a good diagnostic marker with high sensitivity and specificity in both the right and left colon; thus, sigmoidoscopy can be used in the diagnosis of LC using this marker. Aim The aim of the current work is to study the prevalence of MC among patient presented with symptoms of IBS. In addition, it is to determine whether chromogranin A cell density is increased in patients with MC and to examine the possibility of using it as a marker for the diagnosis of LC and collagenous colitis. Patients and methods The study was conducted initially on 100 patients presented with symptoms of IBS according to Rome IV criteria. Overall, 50 patients were excluded after finding an organic cause for their symptoms by diagnostic studies. Results A total of 37 cases were diagnosed as having nonspecific colitis, five cases were diagnosed as having MC (10% of the total cases studied), four cases were found to have ulcerative colitis, three cases was found to have eosinophilic colitis, and one case was found to have melanosis coli. Conclusion The initial results of our study revealed that MC is not an uncommon disease, and there was a significant correlation between using NSAID and proton pump inhibitor and smoking, with cases proved to have MC.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed42    
    Printed2    
    Emailed0    
    PDF Downloaded11    
    Comments [Add]    

Recommend this journal