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ORIGINAL ARTICLE
Year : 2017  |  Volume : 29  |  Issue : 4  |  Page : 189-195

Does brain natriuretic peptide have a significant diagnostic value in subclinical peripheral atrial disease type 2 diabetic patients?


1 Department of Endocrinology and Metabolism, Helwan Faculty of Medicine University, Cairo, Egypt
2 Department of Vascular Surgery, Helwan Faculty of Medicine University, Cairo, Egypt
3 Department of Medical Biochemistry, Assiut Faculty of Medicine, Assiut University, Assiut, Egypt
4 Department of Critical Care Medicine, Helwan Faculty of Medicine University, Cairo, Egypt

Correspondence Address:
Eman M Fahmy
MD of Endocrinology and Metabolism, Faculty of Medicine, Helwan University, Helwan 11795
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejim.ejim_58_17

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Background Peripheral arterial disease (PAD) is a serious complication of diabetes mellitus (DM); it is also correlated with increase in the morbidity and mortality in diabetics owing to cardiovascular disease. Ankle–brachial index (ABI) is an established method to detect PAD. Patients and methods This is a cross-sectional study to detect brain natriuretic peptide (BNP) level in patient with type-2 DM with PAD using ABI. Results This study revealed 11 patients diagnosed with low ABI. Patients with low ABI showed statistical significance regarding mean age (P=0.038), duration of DM (P=0.004), concentration of glycated hemoglobin (P=0.044), BNP (P=0.013), and microalbuminurea (P=0.007). Moreover, patients with low ABI were significantly associated with nephropathy (P=0.001) and retinopathy (P=0.007). BNP at cutoff value of 360 pg/ml had sensitivity and specificity of 27.27 and 95.9, respectively. The BNP level was negatively correlated with the ABI (r=−0.183, P=0.162). BNP showed statistical significance with fasting blood sugar, postprandial glucose, nephropathy, retinopathy, and albumin/creatinine ratio in urine. Conclusion BNP is a potential and a promising biomarker for PAD screening in patients with type-2 DM.


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