• Users Online: 845
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2018  |  Volume : 30  |  Issue : 2  |  Page : 49-53

The relationship between serum dipeptidyl peptidase-4 enzyme and nonalcoholic fatty liver disease in diabetic and nondiabetic patients

1 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt
2 Department of Medical Biochemistry, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt
3 Department of Tropical Medicine, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt

Correspondence Address:
Alaaeldin A Dawood
Department of Internal Medicine, Menoufia University Hospital, Shebin El-Kom 32511
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ejim.ejim_34_17

Rights and Permissions

Background Dipeptidyl peptidase-4 (DPP4) is a membrane-associated peptidase. It has widespread organ distribution throughout the body and exerts pleiotropic effects. The liver expresses DPP4 to a high degree. Nonalcoholic fatty liver disease (NAFLD) is more prevalent in patients with type 2 diabetes mellitus (T2DM), and is associated with increased mortality rates. Currently, there is no approved pharmacologic agent for the management of NAFLD. We need to discover more agents in the pathogenesis of NAFLD to attack it. Therefore, the aim of this work is to study the relationship between serum DPP4 enzyme and NAFLD in diabetic and nondiabetic patients. Patients and methods This study was conducted on 160 patients divided equally into four groups: the control group included healthy participants; the T2DM group included type 2 diabetic patients without NAFLD; the NAFLD group included nondiabetic NAFLD patients; and the T2DM-NAFLD group included T2DM patients with NAFLD. Laboratory investigation included glycosylated hemoglobin, liver enzymes, lipid profile, and serum DPP4 enzyme. Results DPP4 was significantly higher in the T2DM-NAFLD group compared with the other three groups, and in the NAFLD group and T2DM group compared with the control group. There was a significant direct correlation between serum DPP4 and BMI, glycosylated hemoglobin, serum cholesterol, triglycerides, and low-density lipoprotein (LDL). There was a significant inverse correlation between serum DPP4 and high-density lipoprotein (HDL). Conclusion DPP4 is significantly higher in diabetic patients compared with nondiabetic patients and in NAFLD patients compared with non-NAFLD patients. DPP4 can be proposed as a novel candidate in NAFLD pathogenesis.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded198    
    Comments [Add]    

Recommend this journal