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ORIGINAL ARTICLE
Year : 2018  |  Volume : 30  |  Issue : 3  |  Page : 145-153

Do patients with rheumatoid arthritis have aorta stiffer than general population?


1 Clinical Hospital - Bitola, Departments of Internal Medicine and Doppler Ultrasonography, Bitola, Macedonia
2 University Clinic of Obstetrics and Gynecology, University SS, Cyril and Methodius, Skopje, Macedonia
3 Clinical Hospital - Bitola, Departments of Rheumatology and Degenerative Arthropathie, Bitola, Macedonia
4 Faculty of Economics - Prilep, Department of Statistics, St. Celement of Ohrid University, Bitola, Macedonia
5 Institute of Preclinical and Clinical Pharmacology with Toxicology, University SS, Cyril and Methodius, Skopje, Macedonia

Correspondence Address:
Dr. Petar Avramovski
Department of Internal Medicine, Clinical Hospital ‘D-r Trifun Panovski’ Partizanska bb., 7000 Bitola
Macedonia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejim.ejim_65_17

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Objective The aim of this study was to compare the aortic stiffness in patients with rheumatoid arthritis (RA) with the aortic stiffness in general population (GP) and to evaluate the determinants of their stiffness. Patients and methods The study group consisted of 80 patients with RA and 71 matched GP. Pulse wave velocity (PWV) was assessed by Doppler ultrasonography. Biochemical analyses were conducted for serum using standard laboratory procedures. Results The mean PWV values were 7.687±1.03 versus 7.253±0.97 m/s in the patients with RA and GP, respectively. The average coordination of PWV and RA duration (RAD) variations is present by equation of linear regression: y=7.1309+0.0971x. By multiple regression analysis, C-reactive protein, (βst=0.1096, P=0.0009), RAD (βst=0.0917, P=0.0018), high-density lipoprotein cholesterol (βst=−1.0610, P=0.0271), and cholesterol (βst=0.8491, P=0.0350) were independently associated with PWV in the patients with RA. C-reactive protein (βst=0.1057, P=0.0016), triglycerides (βst=0.1730, P=0.0117), low-density lipoprotein cholesterol (βst=0.1467, P=0.0206), and cholesterol (βst=0.0305, P=0.0261) were independently associated with PWV in the GP. Conclusion Arterial stiffness was more pronounced in the patients with RA than in the GP. The independent determinants of arterial stiffness in both groups include traditional risk factors. RAD is determinant in patients with RA only.


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