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ORIGINAL ARTICLE
Year : 2018  |  Volume : 30  |  Issue : 4  |  Page : 204-211

Sensitivity and specificity of ischaemia-modified albumin in detecting diabetic nephropathy


1 Internal Medicine Department, Cairo University, Cairo, Egypt
2 Clinical and Chemical Pathology Department, National Research Center, Cairo, Egypt
3 Internal Medicine Department, Ezbet El Borg Hospital, Cairo, Egypt

Correspondence Address:
Maha Assem Hussein
Department of Internal Medicine, Cairo University, Cairo, 11562
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejim.ejim_30_18

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Background Ischemia-modified albumin (IMA) is a novel marker of tissue ischemia and oxidative stress. Aim We assessed the level of IMA concentration in type 2 diabetes mellitus (T2DM) patients with diabetic nephropathy and its correlation with glycemia level, duration of diabetes, dyslipidemia, serum creatinine, and urinary albumin/creatinine ratio. Patients and methods This study included 91 patients who were divided into three groups: group A (33) included T2DM patients without nephropathy; group B (29) included T2DM patients with nephropathy; and group C (29) included healthy as control. Blood samples were analyzed manually for plasma IMA by spectrophotometric cobalt (II)-albumin-binding assay. Results Serum levels of IMA were significantly higher in group B in comparison to group A with a P value less than 0.001 and group C with a P value less than 0.0001. IMA positively correlated with blood pressure, duration of diabetes, fasting blood glucose, postprandial blood glucose, glycated hemoglobin, cholesterol, low-density lipoprotein, triglycerides, serum creatinine, and albumin/creatinine ratio, all with a P value less than 0.0001 and also with BMI (P<0.003). IMA was a significant discriminator for diabetic nephropathy (P<0.001) with 100% specificity and 100% sensitivity. Conclusion IMA could serve as an indicator of glycemic control and a sensitive marker of diabetic nephropathy.


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