• Users Online: 66
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2019  |  Volume : 31  |  Issue : 2  |  Page : 122-128

Evaluation of microRNA-192 in patients with diabetic nephropathy

1 Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt

Correspondence Address:
Ghada Ahmed
Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, 11731
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ejim.ejim_89_18

Rights and Permissions

Background Diabetic nephropathy (DN) is the leading cause of kidney failure. The role of microRNAs (miRs) which are endogenous RNA oligonucleotides that regulate gene expression in DN is not yet clearly established. This study was designed to evaluate the blood level of miR-192 and its relation to disease severity in patients with type 2 diabetes mellitus with and without DN evidenced by the presence of albuminuria. Materials and methods The study included 60 patients (37 women and 23 men) with type 2 diabetes mellitus and 20 healthy control participants. All were subjected to thorough history taking, clinical evaluation and measurement of glycosylated hemoglobin, creatinine and urinary albumin/creatinine ratio. miR-192 was quantified in blood using reverse transcription TaqMan microRNA assay. Results The study showed that the miR-192 levels were significantly higher in patients with lower estimated glomerular filtration rate and higher albumin/creatinine ratio. Conclusion These findings may help to find a new marker for early detection of DN and this could be used in the future as a novel therapeutic target for the treatment of DN.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded211    
    Comments [Add]    

Recommend this journal