Year : 2015 | Volume
: 27 | Issue : 3 | Page : 103--107
Study of the LMNA 1908 C/T gene polymorphism in type 2 diabetic Egyptians with vascular complications
Heba Mostafa1, Manal Eldeeb1, Ahmed Hamdy1, Rasha M Abdel Samie1, Badawy El-Kholy2, Nahla Fawzy2, Ahmed Eltaweel2, Nahed M Ibrahim2
1 Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt
2 Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt
Vascular complications are the main cause of morbidity and mortality in type 2 diabetic patients. Genetic susceptibility is associated with the evolution of diabetic complications. One such gene is the lamin A and C gene located on chromosome 1q21, a susceptibility locus for type 2 diabetes mellitus, and encodes nuclear lamins A and C. The LMNA 1908 C/T polymorphism has been reported to be associated with dyslipidemia, metabolic syndrome, and obesity, suggesting that this polymorphism increases the risk of atherosclerosis and vascular disease. The present study aims to elucidate the association between the LMNA 1908 C/T single nucleotide polymorphism and the prevalence of vascular complications in a sample of type 2 diabetic Egyptian patients.
Materials and methods
Genomic DNA from 47 type 2 diabetic patients with vascular complications and 20 control participants was analyzed for the LMNA 1908 C/T polymorphism using PCR-RFLP.
Carriers of the LMNA 1908 T-allele showed a significantly higher prevalence in patients with diabetic nephropathy than carriers of the C-allele (P < 0.05). Multiple regression analysis showed that the LMNA 1908 T-allele tended to be independent risk factor for diabetic nephropathy (P = 0.012, odds ratio = 5.460).
The findings of this study suggest that the LMNA 1908 C/T single nucleotide polymorphism is associated with the development of diabetic nephropathy in Egyptian type 2 diabetic patients.
Faculty of Medicine, Cairo University, Kasr Al Aini Street, Cairo 11562
|How to cite this article:|
Mostafa H, Eldeeb M, Hamdy A, Abdel Samie RM, El-Kholy B, Fawzy N, Eltaweel A, Ibrahim NM. Study of the LMNA 1908 C/T gene polymorphism in type 2 diabetic Egyptians with vascular complications.Egypt J Intern Med 2015;27:103-107
|How to cite this URL:|
Mostafa H, Eldeeb M, Hamdy A, Abdel Samie RM, El-Kholy B, Fawzy N, Eltaweel A, Ibrahim NM. Study of the LMNA 1908 C/T gene polymorphism in type 2 diabetic Egyptians with vascular complications. Egypt J Intern Med [serial online] 2015 [cited 2020 May 31 ];27:103-107
Available from: http://www.esim.eg.net/article.asp?issn=1110-7782;year=2015;volume=27;issue=3;spage=103;epage=107;aulast=Mostafa;type=0