The Egyptian Journal of Internal Medicine

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 30  |  Issue : 2  |  Page : 54--57

Study of the serum level of fasting glucagon-like peptide-1 in type 2 diabetics and its relation to the glycemic profile


Mohamed A Korani1, Ahmed Sonbol2 
1 Assistant Professor of Internal Medicine Department, Faculty of Medicine, Menoufia University, Egypt
2 Assistant Professor of Clinical Pathology Department, Faculty of Medicine, Menoufia University, Egypt

Correspondence Address:
Mohamed A Korani
90 Fawzi Moaz Street, Smoha, Alexandria, 21648
Egypt

Background Glucagon-like peptide-1 (GLP-1) is a peptide formed of 30 amino acids. It is synthesized in and released from the enteroendocrine L cells that are present throughout the small and the large intestine. Because of the important physiological role of GLP-1 in augmenting insulin secretion, it is generally believed that GLP-1 release is deficient in type 2 diabetes mellitus (T2DM) patients. However, studies in adults have yielded conflicting results showing decreased, normal, or increased GLP-1 concentrations in prediabetics or T2DM after oral glucose or mixed meal. The aim of this work was to study the level of fasting total GLP-1 in T2DM patients and its relation to the glycemic profile. Patients and methods This study included 60 T2DM patients and 40 participants matched for age and sex as a control group, selected from the inpatient and outpatient clinics of the Internal Medicine Department in Menoufia University Hospital. After obtaining their informed consent, all participants were subjected to a full assessment of history and physical examination with estimation of BMI, insulin resistance with homeostasis model assessment-2, and investigations including fasting blood glucose (FBG), glycated hemoglobin (HbAIc), and the total fasting levels of GLP-1. Results There was no significant difference in the level of GLP-1 between T2DM patients and the controls. There were significant negative correlations between the fasting total GLP-1 and FBG, HbAIc, serum insulin, and homeostasis model assessment-2 in both the total sample and the T2DM patients. Conclusion Fasting total levels of GLP-1 are not reduced in T2DM patients and are negatively correlated with FBG, HbAIc, and insulin resistance.


How to cite this article:
Korani MA, Sonbol A. Study of the serum level of fasting glucagon-like peptide-1 in type 2 diabetics and its relation to the glycemic profile.Egypt J Intern Med 2018;30:54-57


How to cite this URL:
Korani MA, Sonbol A. Study of the serum level of fasting glucagon-like peptide-1 in type 2 diabetics and its relation to the glycemic profile. Egypt J Intern Med [serial online] 2018 [cited 2018 Aug 20 ];30:54-57
Available from: http://www.esim.eg.net/article.asp?issn=1110-7782;year=2018;volume=30;issue=2;spage=54;epage=57;aulast=Korani;type=0