The Egyptian Journal of Internal Medicine

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 31  |  Issue : 3  |  Page : 254--260

Prognostic value of interleukin-10 and tumor necrosis factor-α polymorphisms in patients with hepatocellular carcinoma treated with transarterial chemoembolization


Ahmed A Ghafar1, Elsayed Ghoneem1, Salah Rozaik1, Ahmed Akef2, Metwaly Mortada2 
1 Department of Internal Medicine, Hepatology and Gastroentrology Unit, Faculty of Medicine, Mansoura University, Mansoura, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Correspondence Address:
Ahmed A Ghafar
Department of Internal Medicine, Hepatology and Gastrentrology Unit, Faculty of Medicine, Mansoura University, Mansoura
Egypt

Background Transarterial chemoembolization (TACE), a locoregional therapy, is widely recommended as first-line treatment for intermediate-stage hepatocellular carcinoma (HCC). Several prognostic indices have been used to predict overall survival in HCC patients undergoing the procedure. Patients and methods A total of 73 patients with HCC, candidate for TACE attending to HCC clinic, Specialized Medical Hospital, Mansoura University, were subjected to full history taking, physical examination, laboratory profile and testing for interleukin (IL)-10 and tumor necrosis factor (TNF)-α polymorphisms. Aggressiveness index is calculated for all patients and followed-up for 4 weeks after TACE to asses response. According to IL-10 and TNF-α polymorphisms results, patients were divided into groups and compared. Results The aggressiveness index is significantly higher in the TT/AT haplotype of IL-10 and GG haplotype of TNF-α in comparison with the other haplotypes. The TT/AT haplotype of IL-10 and GG haplotype of TNF-α are significantly associated with less favorable outcome after TACE, wherein 64.3 and 56.25% of patients showed residual active tumor tissue, respectively. Conclusion The TT/AT haplotype of IL-10 and GG haplotype of TNF-α are associated with more aggressive pattern of HCC and less favorable outcome after TACE; hence, these patients must be treated as early as possible.


How to cite this article:
Ghafar AA, Ghoneem E, Rozaik S, Akef A, Mortada M. Prognostic value of interleukin-10 and tumor necrosis factor-α polymorphisms in patients with hepatocellular carcinoma treated with transarterial chemoembolization.Egypt J Intern Med 2019;31:254-260


How to cite this URL:
Ghafar AA, Ghoneem E, Rozaik S, Akef A, Mortada M. Prognostic value of interleukin-10 and tumor necrosis factor-α polymorphisms in patients with hepatocellular carcinoma treated with transarterial chemoembolization. Egypt J Intern Med [serial online] 2019 [cited 2019 Sep 17 ];31:254-260
Available from: http://www.esim.eg.net/article.asp?issn=1110-7782;year=2019;volume=31;issue=3;spage=254;epage=260;aulast=Ghafar;type=0