The Egyptian Journal of Internal Medicine

REVIEW ARTICLE
Year
: 2019  |  Volume : 31  |  Issue : 4  |  Page : 389--396

Extracellular vesicles and systemic lupus erythromatosus


Rasha N Omran1, Emad M El Shebini2, Enas S Zahran2, Sabry A Shoeib2 
1 Department of Internal Medicine, Internal Medicine Department, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt
2 Rheumatology and Immunology Unit, Internal Medicine Department, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt

Correspondence Address:
BSc Rasha N Omran
Berkat Al Sabaar Hospital, Menoufia
Egypt

Introduction Extracellular vesicles (EV) have emerged as important ‘nanoshuttles’ of information between cells, carrying proteins, genetic information, and bioactive lipids to modify the phenotype and function of recipient cells. EVs are potential regulators in autoimmune disorders, playing a determinant role in the appearance and maintenance of inflammation. Objective This study aimed to carry out an up-to-date review of the EVs and their relationship with systemic lupus erythromatosus. Data sources Medline databases (PubMed, Medscape, ScienceDirect, EMF-Portal) and all materials available in the Internet till 2018. Study selection This search yielded 275 articles. The articles were studied to perform an up-to-date review of the extracellular vesicles and their relationship with systemic lupus erythromatosus. Data extraction If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was obtained, the eligibility criteria specified, appropriate controls, and adequate information and defined assessment measures. Data synthesis Comparisons were made by a structured review, with the results tabulated. Conclusion We can safely conclude that EVs play an important role in the complex pathogenesis and management of systemic lupus erythematosus.


How to cite this article:
Omran RN, El Shebini EM, Zahran ES, Shoeib SA. Extracellular vesicles and systemic lupus erythromatosus.Egypt J Intern Med 2019;31:389-396


How to cite this URL:
Omran RN, El Shebini EM, Zahran ES, Shoeib SA. Extracellular vesicles and systemic lupus erythromatosus. Egypt J Intern Med [serial online] 2019 [cited 2020 Sep 22 ];31:389-396
Available from: http://www.esim.eg.net/article.asp?issn=1110-7782;year=2019;volume=31;issue=4;spage=389;epage=396;aulast=Omran;type=0