The Egyptian Journal of Internal Medicine

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 31  |  Issue : 4  |  Page : 934--942

Peripheral blood neutrophils and upregulated surface expression of interleukin-17 and CD177 in patients with bronchial asthma: an association with fungal allergy


Eman E Ahmed, Mohamed K Sabry, Hazem E Abd Elbadie, Nermine A Elnour Melek 
 Department of Internal Medicine, Allergy and Clinical Immunology, Ain Shams University, Cairo, Egypt

Correspondence Address:
BSc, MSc, PhD Nermine A Elnour Melek
42 st Youssef Elsebaii Elrehab City. New Cairo, Cairo, 11865
Egypt

Background Asthma is a prevalent debilitating airway disease, with a tremendous effect worldwide. Fungi and their spores are identified as major culprits in allergic asthma (AA) etiology. Peripheral blood neutrophils and interleukin 17 (IL-17), which are considered crucial players in both bronchial asthma and host defense mechanisms against fungi, increase concomitantly; moreover, certain subsets of neutrophils express and even release IL-17. Objectives In this study, we sought to determine the peripheral frequency of certain neutrophil subpopulations, expressing both CD177 and IL-17, among AA patients, particularly those with fungal allergy. Methods This observational study comprised 40 patients with AA (age range 19–60 years) and 20 age-matched and sex-matched healthy controls (age range 20–55 years). All patients had positive allergy skin prick test results, and accordingly, they were further subdivided into two groups (18 reactive to fungal allergens and 22 to other aeroallergens). The frequency of IL-17+CD177+ neutrophils in the peripheral blood was assessed by flow cytometry in all studied participants. Results The authors observed significantly increased frequency of circulating IL-17+CD177+ neutrophils among AA patients (especially mild to moderate cases) compared with healthy controls (43.3±13.9 vs 15.3±4.8). On the contrary, and surprisingly, patients with fungal allergy and those without did not show any difference with respect to this neutrophil subpopulation (44.6±14.4 vs 42.2±13.7). Conclusion Despite limited sample size, we reported elevated IL-17+CD177+ neutrophil proportion in all AA, regardless of fungal aeroallergenicity. This observation points to a role played by this neutrophil subpopulation in asthma pathophysiology, especially the allergic phenotype, and hopefully offer a new therapeutic approach in asthma management.


How to cite this article:
Ahmed EE, Sabry MK, Abd Elbadie HE, Elnour Melek NA. Peripheral blood neutrophils and upregulated surface expression of interleukin-17 and CD177 in patients with bronchial asthma: an association with fungal allergy.Egypt J Intern Med 2019;31:934-942


How to cite this URL:
Ahmed EE, Sabry MK, Abd Elbadie HE, Elnour Melek NA. Peripheral blood neutrophils and upregulated surface expression of interleukin-17 and CD177 in patients with bronchial asthma: an association with fungal allergy. Egypt J Intern Med [serial online] 2019 [cited 2020 Nov 1 ];31:934-942
Available from: http://www.esim.eg.net/article.asp?issn=1110-7782;year=2019;volume=31;issue=4;spage=934;epage=942;aulast=Ahmed;type=0